DNA/RNA-mutating enzymes are involved in boosting adaptive and innate immunity, ranging
from antibody diversification to restricting viral genomes through mutagenesis and physical
sequestration. With the perspective of the immune response, we work on
several different but
1. We are interested in how DNA/RNA-editing enzymes have evolved in humans and across speciation to contribute to adaptive and innate immunity.
2. We investigate the molecular mechanisms that regulate their roles in immune response.
3. We study the possible outcomes of the mutagenic activities of DNA/RNA-editing enzymes regarding anti-viral or anti-tumor immune response, and...
4. We would like to understand how viruses or cancer cells have adapted to co-evolve with or to subvert t he activities of these host DNA/RNA-editing enzymes.