DNA/RNA-editing enzymes are widely used by biological organisms of all clades towards a diverse range of biological functions including metabolism, immunity and differentiation. However, the enzymes from most species remain uncharacterized and, in many species have remined totally unidentified. One of our goals is identify the DNA/RNA-editing enzyme genes and proteins in all species with sequenced or partially sequenced genomes. We work in collaboration with experts world-wide who focus on different stages of life evolution. Our goal is to characterize the genomics and transcriptomics of DNA/RNA-editing enzymes but we have a particular focus on their structure dynamics, enzyme activity characterization and structure:function evolution.